Nicholas Jeffery
Professor & Mark A. Chapman Chair for Veterinary Strategic InitiativesResearch and Scholarly Interests
Neurology:
- Neuroscience
- Spinal Cord Injury
- Plasticity in the Nervous System
Biography
"I am well-suited to direct projects on spinal cord injury and related topics because they bring together many aspects of my working life over the past 30 years. During this period I have worked partly as a veterinary specialist clinician, providing diagnostics plus both medical and surgical therapy for a range of spinal problems, and partly as a neuroscience PhD, post-doc and PI on laboratory neuroscience projects. In support of my clinical work I have specialist veterinary qualifications in surgery, neurology and spinal surgery. My PhD training at the University of Cambridge was focused on the functional effects of demyelination and remyelination, which ignited my interest in plasticity in the central nervous system and measurement of functional outcomes after nervous system injury that was continued through work as a post-doc at University College London. I am also a founder member of the Canine Spinal Cord Injury Consortium, a group of veterinarians with specific interest in spinal cord injury who have agreed to work together to investigate how to improve therapy for spinal cord injury in dogs and how they can be used as a model for human spinal cord injury. This group provides an ideal background to create a network of collaborating, like-minded, veterinary neurosurgical clinicians to cooperate on this current project.
During the past decade I have become increasingly focused on design and analysis of clinical and bench research projects, and completed a Master’s degree in Clinical Trials from the University of London. This course educated me in clinical trial design, the practicalities of running clinical trials and medical statistics - an ideal training for designing and running the current project. I have already used this training to design and complete two formal randomized controlled clinical trials on novel interventions for chronic spinal cord injury. Much of my focus in running these trials has been to explore and define the degree to which spinal cord injury in dogs can serve as a translational model for human patients, which is also a focus of the current project.
My most recent research has centered on data analysis, particularly quantifying the variability and individuality in functional testing outcomes in rats with spinal cord injury so as to optimally replicate laboratory studies and to use this information to ensure rigorous translation of intervention effects between species. This work has informed my approach to this current project, where the design takes account of the need for alternative methods of individual analysis to enrich outcome assessment."
Education
University of London, London School of Hygiene and Tropical Medicine | London, ENG
Master of Science in Clinical Trials, 2013
University of Cambridge | Cambridge, ENG
Doctor of Philosophy in , 1997
Diplomate of the European College of Veterinary Neurology
Small Animal Neurology, 1995
Diplomate of the European College of Veterinary Surgeons | Zürich, SZ
Soft Tissue Surgery, 1993
University of Bristol, Bristol Veterinary School | Bristol, ENG
Bachelor of Veterinary Science, 1981
Licensure
Texas Vet License: S-553
Honor & Awards
| Award/Honor | Organization | Year |
|---|---|---|
Professional Organizations
Selected Grants
| Conferring Organization | Title | Description |
|---|---|---|
| Morris Animal Foundation – with Unity | Randomized controlled clinical trial of Prevotella histicola supplementation to ameliorate meningoencephalomyelitis of unknown origin |
|
| Keele University (UK) | Protective matrices for delivery of genetically augmented canine olfactory cell transplants. |
|
| International Spinal Research Trust (UK) | Characterization of neurogenic urinary incontinence in the canine model of spinal cord injury using a rage of urodynamic measures. |
|
| n/a | Maureen E Mullins Professorship in Small Animal Clinical Sciences. |
|
| BioMarin Pharmaceutical Inc. | Twenty-six week or longer intracerebroventricular infusion study of BMN 250 administered biweekly in a canine model of mucopolysaccharidosis type IIIB (MPSIIIB). |
|
| Frank K Ramsey endowed chair in Veterinary Medicine | Funds to support research in veterinary medicine (currently used for support of a PhD student in engineering, working on interfaces with CNS). |
|
| McGee-Wagner Foundation (ISU) | Consumable materials for a project to investigate the development of electronic sensor and stimulator for maintaining equilibrium in spinal cord-injured dogs. |
|
| University of Iowa | Funds to support investigations into gait analysis of sheep implanted with intradural electronic stimulators (I-Patch). |
|
| Grayson Jockey Fund | Study on the relationship between transcranial magnetic evoked motor potentials and lesions in the cervical spinal cord of ‘wobbler’ horses. |
|
| International Spinal Research Trust | Clinical trial to define the effectiveness of intraspinal chondroitinase ABC injection as a treatment for severe spinal cord injury in dogs. |
|
| ‘Brown Fellowship’ Award | Garrett McCormack PhD studies on plastic changes in the CNS associated with knee ligament injuries. |
|
| AKC Canine Health Foundation | Potential association between altered gut microbiota and development of meningoencephalomyelitis of unknown etiology (MUE) in dogs |
|
| Wellcome Trust | Visiting student Dan TAGG WT Vacation Studentship |
|
| EPSRC | ~£2M consortium to investigate the growth of peripheral axons through nanotubules. |
|
| Wellcome Trust (with Prof RJM Franklin) | Integrated Veterinary Training Fellowship for John Parker; combined residency training in clinical neurology and PhD studies on the effects of experimental chronic compression on spinal cord white matter. |
|
| Wellcome Trust (with Prof RJM Franklin) | Research Entry Fellowship for Tony Sarma; studies on the effects on the spinal cord dorsal horn of cranial cruciate ligament injury in rats. |
|
| MRC (with Prof RJM Franklin) | Study on effects of olfactory ensheathing cell transplantation into severe spinal cord injuries in dogs. |
|
| Kennel Club Charitable Trust (with Dr S Blott) | Genetic mapping of intervertebral disc disease in Shih Tzu dogs. |
|
| Sasakawa Foundation | Travel between University of Tokyo and University of Cambridge for collaboration on transplantation studies for severe canine spinal cord injury. |
|
| CAMVET award for clinical research (with Dr C Bryant and Mr M Hamilton) | Investigation of the value of measurement of plasma PGE as a clinical test for peritonitis in dogs. |
|
| MRC (with Dr RJM Franklin) | PhD project investigating the functional effects of olfactory glial cell transplantation in spinal cord injury in dogs. |
|
| RCVS Trust Fund (with Mr P Boydell) | Employment of a Resident in Neurology and Neurosurgery. |
|
| Pfizer PLC | Employment costs of a Resident in Neurology. |
|
| RCVS Trust Fund | Studies on clinical aspects of intraspinal glial cell transplantation in dogs. |
|
| BSAVA ‘Petsavers’ | Studies on clinical aspects of intraspinal glial cell transplantation in dogs. |
|
| The Wellcome Trust (with Dr RJM Franklin) | Entry Level Training Fellowship (068829/Z/02/Z) support for a MPhil student for a project to characterise olfactory glial cells in situ in the olfactory system. |
|
| International Spinal Research Trust (with Dr RJM Franklin) | Study of intraspinal transplantation of canine olfactory ensheathing cells for treatment of severe spinal cord injury. |
|
| Kennel Club | Studies on clinical aspects of intraspinal glial cell transplantation in dogs. |
|
| Pet Plan Clinical Studies Trust Fund | Investigation of the pathological features of severe spinal cord injury in the dog. |
|
Undergraduate Teaching
- Establishment of clinical neurology course and delivery of neurology and neurosurgery lectures at the University of Cambridge (UoC) 2000-2010 and Iowa State University (ISU) 2010-present
- Establishment of clinical neurology case rounds, small group teaching, and individual case-based tuition for final-year veterinary students at UoC and ISU
- Introduction of lectures on diagnostic process to penultimate year veterinary students at UoC and ISU
- Lectures on barriers to CNS regeneration to neuroscience MSc students at University College London (1998-2000)
- Practical sessions on neurological examination to veterinary students at UoC and ISU
- Rotation group teaching to students at Texas A&M
Graduate Students
Name |
School |
Description |
Year |
|---|---|---|---|
| Viviana Rojas | University of Cambridge | PhD Student, First-Year Report Examiner | September 2022 |
| Sam Khan | University of Cambridge | PhD Student, First-Year Report Examiner | September 2021 |
| Arthur Sefiani | University of Cambridge, Department of Neuroscience and Experimental Therapeutics | PhD Student, Committee Member | 2020-current |
| Amanda Schuckert | Texas A&M University | PhD Student, Major Professor | 2019-current |
| Michelle Hasiuk | Texas A&M University | MS Student, Major Professor | 2017-2020 |
| Rae Russell | Texas A&M University | PhD Student, Member of Committee, TAMIN | 2016-2019 |
| Nazita Taghavi | Iowa State University, Department of Mechanical Engineering | PhD Candidate, Member of Committee | 2014-2018 |
| Melissa Lewis | North Carolina State University | PhD Defense, Member of POSC | 2016-2017 |
| Shaunik Sharma | Iowa State University, Interdepartmental Neuroscience Program | PhD Student, Member of POSC | 2015-2016 |
| Pongrat Jaisil | Iowa State University | MS Student, Thailand Government Sponsorship | 2015-2016 |
| Hilary Hu | Iowa State University | PhD Student, International Spinal Research Trust | 2013-current |
| Garrett McCormack | Iowa State University | PhD Student | 2012-2016 |
| Nicolas Granger | University of Cambridge | PhD Student, Medical Research Council (UK) | 2008-2011 |
| Tony Sarma | University of Cambridge | MPhil, Welcome Trust | 2008-2009 |
| John Parker | University of Cambridge | PhD Student, Welcome Trust – Combined Residency and PhD Scholarship | 2008-current |
| Lindsay Hamilton | University of Cambridge | PhD Student, Medical Research Council (UK) | 2003-2006 |
| Daisuke Ito | University of Tokyo, University of Cambridge | PhD Student, Co-Supervised | 2004-2007 |
| Alessia Pannese | University of Cambridge | MPhil, Welcome Trust | 2002-2003 |
Journal Articles
Jeffery ND (1988) Treatment of acute and chronic thoracolumbar disc disease by mini hemilaminectomy. J Small Anim Pract 29: 611-616
Jeffery ND (1989) Internal fixation of femoral head and neck fractures in the cat. J Small Anim Pract 30: 674-677
Jeffery ND (1991) Treatment of epidural haemangiosarcoma in a dog. J Small Anim Pract 32: 359-362
Jeffery ND, Thakkar CH, Yarrow TG (1992) Introduction to computed tomography of the canine brain. J Small Anim Pract 33: 2-10
Jeffery ND, Brearley MJ (1992) Cryptococcal osteomyelitis in a dog. J Small Anim Pract 33: 601-604
Smith KC, Brearley MJ, Jeffery ND (1993) Odontoma in a juvenile boxer: clinical, radiographical and pathological features. J Small Anim Pract 34: 142-145
Jeffery ND, Brearley MJ (1993) Brain tumours in the dog: treatment of ten cases and review of recent literature. J Small Anim Pract 34: 367-372
Jeffery ND (1993) Femoral head and neck excision complicated by ischiatic nerve entrapment in two dogs. Veterinary and Comparative Orthopaedics and Traumatology 6: 215-218
Jeffery ND, Smith KC, Franklin RJM, Mayhew IG (1993) Sensory neuronopathy of possible toxic etiology in a dog. Prog Vet Neurol 4: 145-148
Jeffery ND, Phillips SM (1995) Surgical treatment of intramedullary spinal cord neoplasia in two dogs. J Small Anim Pract 36: 553-557
Franklin RJM, Jeffery ND, Ramsey IK (1995) Neuraxonal dystrophy in a litter of papillon pups. J Small Anim Pract 36: 441-444
Jeffery ND, Blakemore WF (1995) Remyelination of mouse spinal cord axons demyelinated by local injections of lysolecithin. J Neurocytol 24: 775-781
Jeffery ND (1996) Dorsal pinning of the atlantoaxial joint - a new surgical treatment for atlantoaxial subluxation. J Small Anim Pract 37: 26-29
Smith KC, Day MJ, Shaw SC, Littlewood JD, Jeffery ND (1996) Canine lymphatoid granulomatosis: an immunophenotypic analysis of three cases. J Comp Pathol 115: 129-138
Jeffery ND, Blakemore WF (1997) Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination. Brain 120: 27-37
Jeffery ND (1999) Peripheral neuropathies in small animals. In Practice 21: 10-18
Jeffery ND, Blakemore WF (1999) Spinal cord injuries in small animals: I. Mechanisms of spontaneous recovery. Vet Record 144: 407-13
Jeffery ND, Blakemore WF (1999) Spinal cord injuries in small animals: II. Current and future options for therapy. Vet Record 145:183-90
Jeffery ND, Crang AJ, O’Leary MT, Hodge SJ, Blakemore WF (1999) Behavioural consequences of oligodendrocyte progenitor cell transplantation into experimental demyelinating lesions in the rat spinal cord. Eur J Neurosci 11: 1508-1514
Jeffery ND, Fitzgerald M (1999) Lack of topographical organisation of the corticospinal tract in the cervical spinal cord of the adult rat. Brain Res 833: 315-318
McKay JS, Targett MP, Jeffery ND (1999) Histological characterisation of an ependymoma in the fourth ventricle of a cat. J Comp Path 120: 105-113.
Brearley MJ, Jeffery ND, Phillips SM, Dennis R (1999) Hypofractionated radiation therapy of brain masses in dogs: a retrospective analysis of survival of 83 cases (1991-1996). J Vet Intern Med 13: 408-412.
Jeffery ND, Yarrow TG (2000) Dura mater laceration associated with acute paraplegia in three dogs. Vet Record. 146: 138-9.
Jeffery ND (2001) Neurological examination of small animals I. In Practice 23: 187196.
Jeffery ND (2001) Neurological examination of small animals II. In Practice 23: 118130.
Jeffery ND, McKee WM. (2001) Surgery for disc-associated wobbler syndrome in the dog--an examination of the controversy. J Small Anim Pract. 42: 574-81.
Gopal MS, Jeffery ND. (2001) Magnetic resonance imaging in the diagnosis and treatment of a canine spinal cord injury. J Small Anim Pract. 42: 29-31.
Jeffery ND, Penderis J, Smith PM, Franklin RJM. (2001) Bridging the divide: spinal cord repair by cellular transplantation--from research laboratory to therapeutic application. J Small Anim Pract. 42: 428-32.
Jeffery ND, Fitzgerald M (2001) Effects of red nucleus ablation and exogenous neurotrophin-3 on corticospinal axon terminal distribution in the adult rat. Neuroscience 104: 513-521
Smith PM, Lakatos A, Barnett SC, Jeffery ND, Franklin RJM.(2002) Cryopreserved cells isolated from the adult canine olfactory bulb are capable of extensive remyelination following transplantation into the adult rat CNS. Exp Neurol. 176: 4026.
Mellanby RJ, Jeffery ND. (2003) What is your diagnosis? Polymyopathy and polyneuropathy. J Small Anim Pract. 44: 153, 189-90.
Jeffery ND, Watson PJ, Abramson C, Notenboom A. (2003) Brain malformations associated with primary adipsia identified using magnetic resonance imaging. Vet Record 152: 436-8.
Mellanby RJ, Jeffery ND, Baines EA, Woodger N, Herrtage ME. (2003) Magnetic resonance imaging in the diagnosis of lymphoma involving the brachial plexus in a cat. Vet Radiol Ultrasound. 44: 522-5.
Jeffery ND (2004) Differential diagnosis of junctionopathies in small animals. In Practice 26: 298-302. Jeffery N (2004) Promoting collaboration and cohesion in veterinary neurology. J Small Anim Pract. 45: 129-30.
Webb AA, Jeffery ND, Olby NJ, and Muir GD. (2004) Behavioural analysis of the efficacy of treatments for injuries to the spinal cord in animals. Vet Rec 155: 225230.
Skinner APC, Pachnicke S, Lakatos A, Franklin RJM, Jeffery ND. (2005) Nasal and frontal sinus mucosa of the adult dog contain numerous olfactory sensory neurons and ensheathing glia. Research in Veterinary Science 78: 9-15.
Jeffery N. (2005) Ethmoidal encephalocoele associated with seizures in a puppy. J Small Anim Pract 46: 89-92.
Mellanby RJ, Jeffery ND, Gopal MS, Herrtage ME. (2005) Secondary hypothyroidism following head trauma in a cat. J Feline Med Surg. 7: 135-9.
Jeffery ND, Lakatos A, Franklin RJM. (2005) Autologous olfactory glial cell transplantation is reliable and safe in naturally-occurring canine spinal cord injury. J Neurotrauma 22: 1282-1293.
Walmsley GL, Herrtage ME, Dennis R, Platt SR, Jeffery ND. (2006) The relationship between clinical signs and brain herniation associated with rostrotentorial mass lesions in the dog. The Veterinary Journal 172: 258-264.
Smith PM, Jeffery ND. (2005) Spinal shock: comparative aspects and clinical relevance. J Am Vet Int Med 19: 788-793.
Ito D, Matsunaga S, Jeffery ND, Sasaki N, Nishimura R, Mochizuki M, Kasahara M, Fujiwara R, Ogawa H (2005) Magnetic Resonance Imaging as a prognostic indicator in dogs with paraplegia caused by thoracolumbar intervertebral disk herniation: 77 cases (2000-2003). J Am Vet Med Assoc. 227:1454–1460.
Jeffery ND, Talbot CE, Smith PM, Bacon NJ. (2006) Acquired idiopathic laryngeal paralysis in dogs is one prominent aspect of generalised neuromuscular disease. Vet Rec 158: 17-20.
Smith PM, Jeffery ND (2006) What’s your diagnosis? A case of intervertebral disc protrusion in a cat. J Small Anim Pract 47: 104-6. Walmsley GL, Smith PM, Herrtage ME, Jeffery ND. (2006) Facial myokymia in a puppy. Vet Rec 158: 411-2.
Smith PM, Haughland SP, Jeffery ND. (2006) Brain Abscess in a Dog Immunosuppressed using Cyclosporin. The Veterinary Journal; E-pub
Ito D, Ibanez C, Ogawa H, Franklin RJ, Jeffery ND. (2006) Comparison of cell populations derived from canine olfactory bulb and olfactory mucosal cultures. Am J Vet Res. 67:1050-6.
Jeffery ND, Smith PM, Lakatos A, Ibanez C, Ito D, Franklin RJ. (2006) Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy. Spinal Cord 44: 584-593.
Smith PM, Jeffery ND (2006) Histological and ultrastructural analysis of white matter damage after naturally-occurring spinal cord injury. Brain Pathol 16: 99-109.
Ibanez C, Ito D, Zawadzka M, Jeffery ND, Franklin RJM (2007) Calponin is expressed by fibroblasts and meningeal cells but not olfactory ensheathing cells in the adult peripheral olfactory system. Glia 55:144-51.
Jeffery ND, Smith PM, Talbot CE (2007) Imaging findings and surgical treatment of hemivertebrae in three dogs. J Am Vet Med Assoc 230: 532-6.
Smith PM, Talbot CE, Jeffery ND (2007) Findings on low-field cranial MR images in epileptic dogs that lack interictal neurological deficits. Vet J May 10; [Epub ahead of print]
Rusbridge C, Jeffery ND (2008) Pathophysiology and treatment of neuropathic pain associated with syringomyelia. Vet J 175: 164–172
Rusbridge C, Carruthers H, Holmes MA, Jeffery ND (2007) Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. J Small Anim Pract 48: 432-436.
Jeffery ND, Smith PM, Chandler S, Kaye R (2007) Acute spinal cord injury in small animals: Part 1 Neurological assessment and diagnostic aids. UK Vet 12 (5): 90-94.
Palmer AC, Jeffery ND, Franklin RJM (2007) Congenital unilateral absence of the corticospinal tract in a Siamese cat. Vet Pathol 44: 949-51.
Jeffery ND, Smith PM, Chandler S, Kaye R (2007) Acute spinal cord injury in small animals: Part 2 Treatment. UK Vet 12 (6): 87-90.
Talbot CE, Mueller K, Granger N, Jeffery ND (2007) MRI diagnosis and surgical removal of brain abscesses in a juvenile alpaca. J Am Vet Med Assoc 231: 1558-61.
Hamilton L, Franklin RJM, Jeffery ND (2007) Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis. BMC Neuroscience 8:77
Stalin CE, Rusbridge C, Granger N, Jeffery ND (2008) Radiographic morphology of the cranial cervical vertebral column in Cavalier King Charles Spaniels and its relationship to syringomyelia. Am J Vet Res 69: 89-93.
Ito D, Fujita N, Ibanez C, Sasaki N, Franklin RJM, Jeffery ND (2008) Serum-free medium provides a clinically relevant method to increase olfactory ensheathing cell numbers in olfactory mucosa cell culture. Cell Transplantation 16: 1021-1027.
Stalin CE, Granger N, Jeffery ND. (2008) Cerebellar vascular hamartoma in a British Shorthair cat. J Feline Med Surg 10: 206-11.
Lefebvre J-B G, Robertson TR, Baines SJ, Jeffery ND, Langley-Hobbs, SJ (2008) Assessment of humeral length in dogs after repair of Salter-Harris type IV fracture of the lateral part of the humeral condyle. Vet Surg 37: 456-462.
Granger N, Stalin CE, Harcourt Brown TB, Jeffery ND (2008) Idiopathic polyradiculoneuropathy in a Bengal cat: electrophysiological findings and 1 year follow-up. J Feline Med Surg 10: 603-7.
Hamilton L, Franklin RJM, Jeffery ND (2008) Quantification of deficits in lateral paw positioning after spinal cord injury in dogs. BMC Veterinary Research 4:47.
Jeffery ND, McBain SC, Dobson J, Chari DM (2009) Uptake of systemically administered magnetic nanoparticles (MNPs) in areas of experimental spinal cord injury (SCI). J Tissue Eng Regen Med 3: 153-7.
Stalin CE, Pratt JNJ, Smith PM, Jeffery ND (2009) Thoracic stenosis causing lateral compression of the spinal cord in two immature Dogues de Bordeaux Veterinary and Comparative Orthopaedics and Traumatology 22: 59-62.
Freeman PM, Harcourt-Brown TR, Jeffery ND, Granger N. (2009) Electrophysiologic evidence of polyneuropathy in a cat with signs of bilateral brachial plexus neuropathy. JAVMA 234: 240-244
Cashmore RG, Harcourt-Brown TR, Freeman PM, Jeffery ND, Granger N (2009) Clinical diagnosis and treatment of suspected neuropathic pain in three dogs. Australian Veterinary Journal 87: 45-50.
Granger N, Smith PM, Jeffery ND (2010) Clinical findings and treatment of noninfectious meningoencephalomyelitis in dogs: A systematic review of 457 published cases from 1962 to 2008. Vet J. 184: 290-7.
Harcourt-Brown TR, Granger N, Smith PM, Hughes K, Jeffery ND (2009) Use of a lateral surgical approach to the femoral nerve in the management of two primary femoral nerve sheath tumours. VCOT 22: 229-232.
Smith PM, Stalin CE, Shaw D, Granger N, Jeffery ND (2009) Comparison of two regimens for the treatment of meningoencephalomyelitis of unknown etiology. JVIM 23: 520-526.
Carruthers H, Rusbridge C, Dubé M-P, Holmes M, Jeffery N (2009) Association between cervical and intracranial dimensions and syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract 50: 394-398.
Ito D, Okada M, Jeffery ND, Kitagawa M, Uchida K, Watari T (2009) Symptomatic tongue atrophy due to atypical polymyositis in a pembroke welsh corgi. J Vet Med Sci 71: 1063-7.
Alves de Medeiros M, Startin CM, Jeffery ND (2009) Innervation of canine skin: an immunohistochemical study. Vet Rec 165: 314-318.
Demetriou JL, Geddes RF, Jeffery ND (2009) Survey of pet owners' expectations of surgical practice within first opinion veterinary clinics in Great Britain. J Small Anim Pract 50: 478-87.
Panti A, Bennett RC, Corletto F, Brearley J, Jeffery N, Mellanby RJ (2009) The effect of omeprazole on oesophageal pH in dogs during anaesthesia. J Small Anim Pract 50: 540-4.
Tatton B, Jeffery N, Holmes M (2009) Predicting recovery of urination control in cats after sacrocaudal injury: a prospective study. J Small Anim Pract 50: 593-596.
Garosi L, Dawson A, Couturier J, Matiasek L, de Stefani A, Davies E, Jeffery N, Smith P (2010) Necrotizing Cerebellitis and Cerebellar Atrophy Caused by Neospora caninum Infection: Magnetic Resonance Imaging and Clinicopathologic Findings in Seven Dogs. J Vet Intern Med Mar 15. [Epub ahead of print]
Sanchez-Bustinduy M, de Medeiros MA, Radke H, Langley-Hobbs S, McKinley T, Jeffery N (2010) Comparison of Kinematic Variables in Defining Lameness Caused by Naturally Occurring Rupture of the Cranial Cruciate Ligament in Dogs. Vet Surg 39: 523-30.
Greenhalgh SN, Dunning MD, McKinley TJ, Goodfellow MR, Kelman KR, Freitag T, O'Neill EJ, Hall EJ, Watson PJ, Jeffery ND (2010) Comparison of survival after surgical or medical treatment in dogs with a congenital portosystemic shunt. J Am Vet Med Assoc 236: 1215-20.
Hayes GM, Friend EJ, Jeffery ND (2010) Relationship between pharyngeal conformation and otitis media with effusion in Cavalier King Charles spaniels. Vet Rec 167: 55-8.
Jeffery ND (2010) Vertebral fracture and luxation in small animals. Vet Clin North Am Small Anim Pract. 40: 809-28. Hayes GM, Langley-Hobbs SJ, Jeffery ND (2010) Risk factors for medial meniscal injury in association with cranial cruciate ligament rupture. J Small Anim Pract 51: 630–634.
Harcourt-Brown TR, Parker JE, Granger N, Jeffery ND (2010) Effect of middle ear effusion on the brain-stem auditory evoked response of Cavalier King Charles Spaniels. Vet J. 188: 341-5.
Jeffery ND, Hamilton L, Granger N (2011) Designing clinical trials in canine spinal cord injury as a model to translate successful laboratory interventions into clinical practice. Vet Rec 168: 102-107.
de Medeiros M, Sánchez Bustinduy M, Radke H, Langley-Hobbs S, Jeffery N (2011) Early kinematic outcome after treatment of cranial cruciate ligament rupture by tibial plateau levelling osteotomy in the dog. Vet Comp Orthop Traumatol 24: 178-184.
Harcourt-Brown TR, Belshaw Z, Parker JE, Jeffery ND, Granger N (2011) Effects of syringomyelia on electrodiagniostic test results in Cavalier King Charles Spaniels. Am J Vet Res 72: 595-600.
Parker JE, Knowler SP, Rusbridge C, Noorman E, Jeffery ND (2011) Prevalence of asymptomatic syringomyelia in Cavalier King Charles spaniels. Vet Rec 168: 667.
Ito D, Kitagawa M, Jeffery N, Okada M, Yoshida M, Kobayashi M, Nakamura A, Watari T (2011) Dystrophin-deficient muscular dystrophy in an Alaskan malamute. Vet Rec 169: 127.
Vanhaesebrouck AE, Shelton GD, Garosi L, Harcourt-Brown TR, Couturier J, Behr S, Harvey RJ, Jeffery ND, Matiasek K, Blakemore WF, Granger N (2011) A Novel Movement Disorder in Related Male Labrador Retrievers Characterized by Extreme Generalized Muscular Stiffness. J Vet Intern Med. 25: 1089-1096.
Hu H, Rusbridge C, Constantino-Casas F, Jeffery ND (2012) Histopathological investigation of syringomyelia in the Cavalier King Charles spaniel. J Comp Path 146: 192-201.
Hu H, Rusbridge C, Constantino-Casas F, Jeffery ND (In press) Distribution of substance P and calcitonin gene-related peptide in the spinal cord of Cavalier King Charles Spaniels affected by symptomatic syringomyelia. Res Vet Sci
Howard III MA, Utz M, Brennan TJ, Dalm BD, Viljoen S, Jeffery ND, Gillies GT (2011) Intradural approach to selective stimulation in the spinal cord for treatment of intractable pain: design principles and wireless protocol. J Appl Phys 110: 044702-1 – 044702-12.
Nicholson I, Langley-Hobbs S, Sutcliffe M, Jeffery N, Radke H (2012) Feline talocrural luxation: A cadaveric study of repair using ligament prostheses. Vet Comp Orthop Traumatol 25: 116-25
Oya H, Reddy CG, Dahdaleh NS, Wilson S, Howard III MA, Jeffery ND, Utz M, Gillies GT. (2012) Applier tool for intradural spinal cord implants. J Med Eng Technol 36: 169-173.
Barker AK, Stahl C, Ensley SM, Jeffery ND (2013) Tremorgenic mycotoxicosis in dogs. Compend Contin Educ Vet. 2013; 35: E2.
Granger N, Blamires H, Franklin RJM, Jeffery ND. (2012) Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized, double-blinded trial in a canine translational model. Brain 135: 3227-37.
Granger N, Chew D, Fairhurst P, Fawcett JW, Lacour SP, Craggs M, Mosse CA, Donaldson N, Jeffery ND (2013) Use of an implanted sacral nerve stimulator to restore urine voiding in chronic paraplegic dogs. J Vet Intern Med 27: 99-105.
Williams JM, Riedesel EA, Jeffery ND, Alcott CJ. (2014) What is your diagnosis? Subdural empyema in a German Shepherd Dog. J Am Vet Med Assoc. 245: 175177.
Flouty O, Oya H, Kawasaki H, Wilson S, Reddy CR, Jeffery ND, Brennan TJ, Gibson-Corley KN, Utz M, Gillies GT, Howard III MA (2012) A new device concept for directly modulating spinal cord pathways: initial in vivo experimental results. Physiological Measurements 33: 2003-2015.
Hayes GM, Granger N, Langley-Hobbs SJ, Jeffery ND (2013) Abnormal reflex activation of hamstring muscles in dogs with cranial cruciate ligament rupture. Vet J 196: 345-50.
Gibson-Corley KN, Oya H, Flouty O, Fredericks DC, Jeffery ND, Gillies GT, and Howard III MH. (2012). Ovine Tests of a Novel Spinal Cord Neuromodulator and Dentate Ligament Fixation Method. J Investigative Surgery 25: 366-374.
Flouty OE, Oya H, Kawasaki H, Reddy CG, Fredericks DC, Gibson-Corley KN, Jeffery ND, Gillies GT, Howard III, MA. (2013) Intracranial somatosensory responses with direct spinal cord stimulation in anesthetized sheep. PLoS One 8: e56266.
McGuinness SJ, E. J. Friend EJ, Knowler SP, Jeffery ND, Rusbridge C (2013). Progression of otitis media with effusion in the Cavalier King Charles spaniel. Veterinary Record 172: 315-316.
Van Wie EY, Fosgate GT, Mankin JM, Jeffery ND, Kerwin SC, Levine GJ, Greatting HH, Chen AV, Barker AK, Levine JM (2013) Prospectively Recorded versus Medical Record-Derived Spinal Cord Injury Scores in Dogs with Intervertebral Disk Herniation. J Vet Intern Med 27: 1273-7.
Freeman P, Holmes MA, Jeffery ND, Granger N (2013) Time requirement and impact on owners of home-based management of dogs with severe chronic spinal cord injury. Journal of Veterinary Behavior 8: 439-443.
Jeffery ND, Levine JM, Olby NJ, Stein V (2013) Intervertebral disc degeneration in dogs: consequences, diagnosis, treatment and future directions. J Vet Intern Med 27: 1318-33
Oya H, Safayi S, Jeffery ND, Viljoen S, Reddy CG, Dalm BD, Kanwal JK, Gillies GT, Howard III MA (2013). Soft-Coupling Suspension System for an Intradural Spinal Cord Stimulator: Biophysical Performance Characteristics. Journal of Applied Physics 114, 164701 (2013); http://dx.doi.org/10.1063/1.4827195
Granger N, Franklin RJM, Jeffery ND (2014) Cell therapy for spinal cord injury – what’s really going on? Neuroscientist. 20: 623-638
Greenhalgh SN, Dunning MD, Goodfellow MR, Freitag T, O'Neill EJ, Hall EJ, Watson PJ, Jeffery ND. (2014) Comparison of survival after surgical or medical treatment in dogs with a congenital portosystemic shunt - Long-term follow-up. J Am Vet Med Assoc 245: 527-33.
Safayi S, Jeffery ND, Fredericks DC, Viljoen S, Dalm, BD, Reddy CG, Wilson S, Gillies GT, Howard MA. (2014) Biomechanical Performance of an Ovine Model of Intradural Spinal Cord Stimulation. Journal of Medical Engineering & Technology 38: 269-273.
Barker A, Williams JM, Chen A, Bagley R, Jeffery ND. (2015) Magnetic resonance imaging characteristics of primary hematomyelia in 3 dogs. Canadian Veterinary Journal 56: 278-84.
Jeffery ND, Barker A, Harcourt-Brown, T. (2014) What progress has been made in understanding and treatment of degenerative lumbosacral stenosis in dogs during the past 30 years? Vet J 201: 9-14.
Jeffery ND. (2014) Corticosteroid use in small animal neurology. Veterinary Clinics of North Am Small Anim Pract 44: 1059-74.
Harcourt-Brown TR, Campbell J, Warren-Smith C, Jeffery ND, Granger NP. (2014) Prevalence of Chiari-like Malformations in Clinically Unaffected Dogs.J Vet Intern Med. 29: 231-7.
Charalambous M, Jeffery ND, Smith PM, Goncalves R, Barker A, Hayes G, Ives E, Vanhaesebrouck AE. (2014) Surgical treatment of dorsal hemivertebrae associated with kyphosis by spinal segmental stabilisation, with or without decompression. Vet J. 202: 267-73.
Coates JR, Jeffery ND. (2014) Perspectives on meningoencephalomyelitis of unknown origin. Vet Clin North Am Small Anim Pract 44: 1157-85.
Dalm BD, Viljoen SV, Dahdaleh NS, Reddy CG, Brennan TJ, Oya H, Wilson S, Sfayi S, Jeffery ND, Gilles GT, Howard MA (2014) Revisiting intradural spinal cord stimulation: an introduction to a novel intradural sinal cord stimulation device. Innovative Neurosurgery 2: 13-20.
Jeffery ND, Barker A, Alcott C, Kraus KH, Shivapour S, Hu HZ, Granger N, Levine JM. (2016) Factors associated with recovery from paraplegia in dogs with loss of pain perception in the pelvic limbs following intervertebral disk herniation. JAVMA 248: 386-94.
Kwon BK, Streijger F, Hill CE, Anderson AJ, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, Houle JD, Jakeman LB, Jeffery ND, Jones LA, Kleitman N, Kocsis J, Lu P, Magnuson DS, Marsala M, Moore SW, Mothe AJ, Oudega M, Plant GW, Rabchevsky AS, Schwab JM, Silver J, Steward O, Xu XM, Guest JD, Tetzlaff W. (2015) Large Animal and Primate Models of Spinal Cord Injury for the Testing of Novel Therapies. Exp Neurol 269: 154-68.
Hu H, Jeffery ND, Donnelly JL, Lindquist T, Gilmour L, Flaherty H, Barker A (2016) What’s your neurologic diagnosis?: A case of feline toxoplasmosis. JAVMA 249: 1007-1010.
Plessas J, Volk H, Rusbridge C, Vanhaesebrouck A, Jeffery N. (2015) Comparison of gabapentin versus topiramate on clinically affected dogs with Chiari-like malformation and syringomyelia. Veterinary Record 177: 288.
Hu H, Barker A, Harcourt-Brown T, Jeffery N (2015) Systematic review of brain tumor treatment in dogs. JVIM 29: 1456-63.
Safayi S, Jeffery ND, Shivapour SK, Zamanighomi M, Zylstra TJ, Bratsch-Prince J, Wilson S, Reddy CG, Fredericks DC, Gillies GT, Howard MA (2015) Kinematic analysis of the gait of adult sheep during treadmill locomotion: parameter values, allowable total error, and potential for use in evaluating spinal cord injury. J Neurol Sci 358: 107-12.
Safayi S, Miller JW, Wilson S, Shivapour SK, Oelfke TF, Ford AL, Klarman Staudt A, Abode-Iyamah K, Reddy CG, Jeffery ND, Fredericks DC, Gillies GT, Howard MA (2016). Treadmill measures of ambulation rates in ovine models of spinal cord injury and neuropathic pain. Journal of Medical Engineering & Technology. 40: 72-79.
Hepworth-Warren KL, Wiechert SA, Miles KG, Jeffery ND, Wong D (2016) Magnetic resonance imaging of presumptive neonatal encephalopathy in a foal. Equine Veterinary Education doi: 10.1111/eve.12590
Russell RL, Levine JM, Jeffery ND, Young C, Mondragon A, Lee B, Boudreau CE, Welsh CJ, Levine GJ. (2016) Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury. BMC Neuroscience 17: 31.
Hu HZ, Granger N, Jeffery ND (2016) Pathophysiology, clinical significance and management of neurogenic lower urinary tract dysfunction caused by supra-sacral spinal cord injury. JVIM 30: 1575-1588.
Wilson S, Abode-Iyamah K, Miller JW, Reddy C, Safayi S, Fredericks D, Jeffery N, Devries N, Shivapour SK, Viljoen S, Dalm B, Gibson-Corley K, Johnson M, Howard M. (2016) An Ovine Model of Spinal Cord Injury. J Spinal Cord Med 19: 1-15
Dhillon RS, Parker J, Syed Y, Edgley S, Young A, Fawcett J, Jeffery N, Franklin R, Kotter M. (2016) Axonal plasticity underpins the functional recovery following surgical decompression in a rat model of cervical spondylotic myelopathy. Acta Neuropathologica Communications 4: 89.
Taghavi N, Luecke GR, Jeffery ND. (2016) A bionic test-bed for sensing and balance augmentation in biological applications. Proc ASME Paper No. IMECE2016-67673, pp. V04AT05A021; 8 pages doi:10.1115/IMECE2016-67673
Yaw TJ, Jeffery ND, Cain B, Fales-Williams A, Zaffarano BA. (2016) Removal of a Presumed Peripheral Cerebral Cyst via Craniectomy in a Crested Pekin Duck (Anas platyrhynchos f dom). J Avian Med Surg 30: 263-268.
Gilmour L, Jeffery ND, Miles K, Riedesel E. (2017) Comparison of a Single Shot Turbo Spin Echo Pulse Sequence in Dogs with and without Progressive Myelomalacia: An Exploratory Study. Vet Radiol Ultrasound 58: 197-205. Freeman P, Jeffery ND (2017) Re-opening the window on fenestration as treatment for acute thoracolumbar intervertebral disc herniation in dogs. J Small Anim Pract 58: 199-204.
Jeffery ND, Barker AK, Alcott CJ, Levine JM, Meren I, Wengert J, Jergens AE, Suchodolski JS (2017) The association of specific constituents of the fecal microbiota with immune-mediated brain disease in dogs. PLoS One 12: e0170589.
Moore SA, Granger N, Olby NJ, Spitzbarth I, Jeffery ND, Tipold A, Nout-Lomas YS, da Costa RC, Stein VM, Noble-Haeusslein LJ, Blight AR, Grossman RG, Basso DM, Levine JM. (2017) Targeting Translational Successes through CANSORT-SCI: Using Pet Dogs To Identify Effective Treatments for Spinal Cord Injury. J Neurotrauma 34: 2007-2018.
Meren IL, Chavera JA, Alcott CJ, Barker AK, Jeffery ND (2017) Shunt tube placement for amelioration of cerebrospinal fluid flow obstruction caused by spinal cord subarachnoid fibrosis in dogs. Vet Surg 46: 289-296.
Charalambous M, Bhatti SFM, Van Ham L, Platt S, Jeffery ND, Tipold A, Siedenburg J, Volk HA, Hasegawa D, Gallucci A, Gandini G, Musteata M, Ives E, Vanhaesebrouck AE. (2017) Intranasal Midazolam versus Rectal Diazepam for the Management of Canine Status Epilepticus: A Multicenter Randomized Parallel-Group Clinical Trial. J Vet Intern Med. 2017 May 24. doi: 10.1111/jvim.14734.
Swinbourne F, Jeffery N, Tivers MS, Artingstall R, Bird F, Charlesworth T, Doran I, Freeman A, Hall J, Hattersley R, Henken J, Hughes J, de la Puerta B, Rutherford L, Ryan T, Williams H, Woods S, Nicholson I. (2017) The incidence of surgical site dehiscence following full-thickness gastrointestinal biopsy in dogs and cats and associated risk factors. J Small Anim Pract Aug 1. doi: 10.1111/jsap.12696. [Epub ahead of print]
Benchekroun G, Desquilbet L, Herrtage ME, Jeffery ND, Rosenberg D, Granger N (2017). Dogs with macroadenomas have lower body temperature and heart rate than dogs with microadenomas. Vet J 227:42-45.
Jeffery ND, Freeman PM (2017). The Role of Fenestration in Management of Type I Thoracolumbar Disk Degeneration. Vet Clin North Am Small Anim Pract. 2017 Oct 23. pii: S0195-5616(17)30101-8. doi: 10.1016/j.cvsm.2017.08.012.
Jeffery ND, Harcourt-Brown TR, Barker AK, Levine JM (2017). Choices and Decisions in Decompressive Surgery for Thoracolumbar Intervertebral Disk Herniation. Vet Clin North Am Small Anim Pract. 2017 Oct 23. pii: S01955616(17)30103-1. doi: 10.1016/j.cvsm.2017.08.014.
Jeffery N, Boudreau CE, Konarik M, Mays T, Fajt V. (2018) Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury. PeerJ. 26; 6: e4387.
Hu HZ, Granger N, Pai SB, Bellamkonda RV, Jeffery ND. (2018) Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury. Brain 141: 1017-1027.
Ito D, Ishikawa C, Jeffery ND, Ono K, Tsuboi M, Uchida K, Yamato O, Kitagawa M. (2018) Two-Year Follow-Up Magnetic Resonance Imaging and Spectroscopy Findings and Cerebrospinal Fluid Analysis of a Dog with Sandhoff's Disease. J Vet Intern Med 32: 797-804.
Doocy KR, Saunders AB, Gordon SG, Jeffery N. (2018) Comparative, multidimensional imaging of patent ductus arteriosus and a proposed update to the morphology classification system for dogs. J Vet Intern Med 32: 648-657.
Smith BD, Vail KJ, Carroll GL, Taylor MC, Jeffery ND, Vemulapalli TH, Elliott JJ. (2018) Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Xenopus laevis).J Am Assoc Lab Anim Sci 57: 202-209.
Jeffery ND, Bate ST, Safayi S, Howard MA 3rd, Moon L, Jeffery U. (2018) When neuroscience met clinical pathology: partitioning experimental variation to aid data interpretation in neuroscience. Eur J Neurosci 47: 371-379.
Taghavi N, Luecke GR, Jeffery ND. (2018) A Wearable Body Controlling Device for Application of Functional Electrical Stimulation. Sensors (Basel) 18 pii: E1251.
Hu HZ, Jeffery ND, Granger N (2018). Somatosensory and motor evoked potentials in dogs with chronic severe thoracolumbar spinal cord injury. The Veterinary Journal 237: 49-54.
Taghavi N, Luecke GR, Jeffery ND (2018) A Review on Electromechanical Methods and Devices for Neural Rehabilitation. 1(2). Evolutions in Mechanical Engineering 000508.2018. DOI: 10.31031/EME.2018.01.000508
Moore SA, Zidan N, Spitzbarth I, Nout-Lomas YS, Granger N, da Costa RC, Levine JM, Jeffery ND, Stein VM, Tipold A, Olby NJ (2018). Development of an International Canine Spinal Cord Injury observational registry: a collaborative data-sharing network to optimize translational studies of SCI. Spinal Cord 56: 656-665.
Proot JLJ, Jeffery N, Culp WTN, Buracco P, de la Puerta B, Williams JM, Ladlow JF, Field EJ, Nelissen P, Ragni RA, Pope JFA, Baines SJ, Liptak JM, Nicholson I. (2019) Is the caudal auricular axial pattern flap robust? A multi-centre cohort study of 16 dogs and 12 cats (2005 to 2016). J Small Anim Pract 60: 102-106
Wesselowski S, Cusack K, Gordon SG, Jeffery N, Saunders AB. (2019) Artificial cardiac pacemaker placement in dogs with a cohort of myocarditis suspects and association of ultrasensitive cardiac troponin I with survival. J Vet Cardiol 22:84-95.
Schmidli FE, Stein VM, Aikawa T, Boudrieau RJ, Jeandel A, Jeffery N, Jurina K, Moissonnier P, Rupp S, Vidondo B, Forterre F (2019). Fractures of the Second Cervical Vertebra in 66 Dogs and 3 Cats: A Retrospective Study. Vet Comp Orthop Traumatol 32: 200-206.
Ito D, Carwardine D, Prager J, Wong LF, Kitagawa M, Jeffery N, Granger N (2019) Methods of olfactory ensheathing cell harvesting from the olfactory mucosa in dogs. PLoS One 14: e0213252.
Shivapour SK, Jackson ND, Schleining JA, Kreuder AJ, Miles KG, Jeffery ND (2019) Surgical intervention for vertebral osteomyelitis in a calf. Vet Surg 48: 1064-1070.
Harcourt-Brown T, Granger N, Fitzpatrick N, Jeffery ND (2019) Electrodiagnostic features of degenerative lumbosacral stenosis. J Vet Intern Med doi: 10.1111/jvim.15589. [Epub ahead of print]
Worth A, Meij B, Jeffery N (2019) Canine degenerative lumbosacral stenosis: prevalence, impact and management strategies. Veterinary Medicine: Research and Reports 10: 169-183.
Taghavi, N, Luecke, GR, Jeffery ND (2019) A Neuro-Prosthetic Device for Substituting Sensory Functions during Stance Phase of the Gait. Appl. Sci. 9, 5144.
Allerton F, Jeffery N (2020) Prescription rebellion: reduction of antibiotic use by small animal veterinarians. J Small Anim Pract.
Andruzzi MN, Mankin JM, Lau CH, Ploeg RJ, Grami ZA, Jeffery ND (2020) Lymphoma in the brain of a dog. J Small Anim Pract doi: 10.1111/jsap.13095. [Epub ahead of print]
Ito D, Ishikawa C, Jeffery ND, Oshima A, Nakayama T, Kitagawa M (2020) 'T-SLIP' MRI imaging of cerebrospinal fluid flow through the mesencephalic aqueduct. J Small Anim Pract doi: 10.1111/jsap.13106. [Epub ahead of print]
Taghavi N, Luecke GR, Jeffery ND (2020) Review: A technical review on development of an advanced electromechanical system. Computers 9: 19 doi:10.3390/computers9010019
Olby N, Griffith E, Levine JM, CANSORT-SCI* (2020) Comparison of Gait Assessment Scales in Dogs with Spinal Cord Injury due to Intervertebral Disc Herniation. J Neurotrauma. 2020 Jan 9. doi: 10.1089/neu.2019.6804. *NJ as part of CANSORT
Ito D, Shiozawa N, Sekiguchi N, Ishikawa C, Jeffery ND, Kitagawa M (2020) Repeated surgical treatment and long-term outcome of a cat with vertebral vascular hamartoma. J Vet Med Sci. 2020 Apr 16. doi: 10.1292/jvms.
Jeffery ND, Mankin JM, Ito D, Boudreau CE, Kerwin SC, Levine JM, Krasnow MS, Andruzzi MN, Alcott CJ, Granger N (2020) Extended durotomy to treat severe spinal cord injury after acute thoracolumbar disc herniation in dogs. Vet Surg. 2020 Apr 11. doi: 10.1111/vsu.
Williams A, Gow AG, Kilpatrick S, Tivers MS, Lipscomb V, Smith K, Day MJ, Jeffery ND, Mellanby RJ (2020) Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital portosystemic shunting. J Vet Sci 21: e44. doi: 10.4142/jvs.2020.21.e44.
Fenn J, Ru H, Jeffery ND, Moore S, Tipold A, Soebbeler FJ, Wang-Leandro A, Mariani CL, Early PJ, Muñana KR, Olby NJ (2020) Association between anesthesia duration and outcome in dogs with surgically treated acute severe spinal cord injury caused by thoracolumbar intervertebral disk herniation. J Vet Intern Med doi: 10.1111/jvim.15796.
Jeffery ND, Brakel K, Aceves M, Hook M, Jeffery UB (2020) Variability in open-field locomotor scoring following force-defined spinal cord injury in rats: quantification and implications. Frontiers in Neurology, section Neurotrauma (in press)
Russell J, Jeffery N, Bailey J, Osborn S,Le-Bert C, Whitehead H, Nollens, H. (In press) CEREBROSPINAL FLUID SAMPLING IN A BOTTLENOSE DOLPHIN (TURSIOPS TRUNCATUS) UNDER GENERAL ANESTHESIA. Journal of Zoo and Wildlife Medicine.
Aceves M, Dietz VA, Dulin JN, Jeffery U, Jeffery ND (2020) An analysis of variability in 'CatWalk' locomotor measurements to aid experimental design and interpretation. eNeuro: ENEURO.0092-20.2020. doi: 10.1523/ENEURO.0092-20.2020.
Jeffery ND, Olby NJ, Moore SA; Canine Spinal Cord Injury Consortium (CANSORTSCI) (2020) Clinical Trial Design-A Review-With Emphasis on Acute Intervertebral Disc Herniation. Front Vet Sci 7: 583.
Cusack K, Wesselowski S, Saunders AB, Jeffery N (2020) Correlations between age, body size, sex, and conformation and ultrasound-measured femoral vessel diameter in the dog, with implications for transvascular procedural planning. Vet Radiol Ultrasound. 2020 Oct 31. doi: 10.1111/vru.12920.
Ito D, Ishikawa C, Jeffery ND, Kitagawa M. (2020) Intraventricular carcinoma in a dog. J Small Anim Pract. 2020 Sep 28. doi: 10.1111/jsap.13228
Lewis MJ, Jeffery ND, Olby NJ; Canine Spinal Cord Injury Consortium (CANSORTSCI) (2020) Ambulation in Dogs With Absent Pain Perception After Acute Thoracolumbar Spinal Cord Injury. Front Vet Sci. 7: 560. doi: 10.3389/fvets.2020.00560. eCollection 2020.
Boudreau CE, Otamendi A, Levine JM, Griffin JF, Gilmour L, Jeffery ND. (2020) Relationship between machine-learning image classification of T2-weighted intramedullary hypointensity on 3T MRI and clinical outcome in dogs with severe spinal cord injury. J Neurotrauma. 2020 Oct 14. doi: 10.1089/neu.2020.7188.
Ito D, Ishikawa C, Sekiguchi N, Jeffery ND, Kitagawa M. (2020) Utility of "MR myelography" in diagnosis of a presumed spinal subarachnoid diverticulum. J Small Anim Pract. 2020 Oct 12. doi: 10.1111/jsap.13208.
Emerging and Adjunctive Therapies for Spinal Cord Injury Following Acute Canine Intervertebral Disc Herniation. Lewis MJ, Granger N, Jeffery ND; Canine Spinal Cord Injury Consortium (CANSORT-SCI). Front Vet Sci. 2020 Oct 15;7:579933.
Association of magnetic resonance assessed disc degeneration and late clinical recurrence in dogs treated surgically for thoracolumbar intervertebral disc extrusions. Longo S, Gomes SA, Briola C, Duffy K, Targett M, Jeffery ND, Freeman P.J Vet Intern Med. 2020 Dec 7. doi: 10.1111/jvim.15989.
Jeffery U, Jeffery ND, Creevy KE, Page R, Simpson MJ (2021) Variation in biochemistry test results between annual wellness visits in apparently healthy Golden Retrievers. J Vet Intern Med Feb 2. doi: 10.1111/jvim.16021.
Ito D, Ishikawa C, Jeffery ND, Kitagawa M (2021) Cerebrospinal fluid flow on timespatial labeling inversion pulse images before and after treatment of congenital hydrocephalus in a dog. J Vet Intern Med doi: 10.1111/jvim.16020.
Beasley MJ, Hiebert EC, Alcott C, Jeffery N, LaFoon-Jones B, Gambino JM (2021) Verminous myelopathy secondary to aberrant Dirofilaria immitis migrans was detected in the cervical subarachnoid space of four dogs using MRI and CT. Vet Radiol Ultrasound doi: 10.1111/vru.12954.
Saadoun S, Jeffery ND (2021) Acute Traumatic Spinal Cord Injury in Humans, Dogs, and Other Mammals: The Under-appreciated Role of the Dura. Front Neurol 12:629445. doi: 10.3389/fneur.2021.629445.
Thieman Mankin KM, Jeffery ND, Kerwin SC (2021) The impact of a surgical checklist on surgical outcomes in an academic institution. Vet Surg Apr 1. doi: 10.1111/vsu.13629.
Andruzzi MN, Voges AK, Russell KE, Jeffery ND (2021) Brachial artery thrombosis in a dog causing monoparesis mimicking nerve sheath tumor. J Vet Intern Med doi: 10.1111/jvim.16213.
Wesselowski S, Cusack K, Saunders AB, Jeffery N (2022) Pre-procedural femoral vessel ultrasound in dogs with patent ductus arteriosus: diameter, image quality and relationship with arterial catheterization. J Vet Cardiol. 2022 Feb;39:69-78. doi: 10.1016/j.jvc.2021.12.004.
Schrock K, Kerwin SC, Jeffery N (2021) Outcomes and Complications Associated with Acute Gunshot Fractures in Cats and Dogs. Vet Comp Orthop Traumatol. 2021 Dec 7. doi: 10.1055/s-0041-1739238.
Krasnow MS, Griffin JF 4th, Levine JM, Mai W, Pancotto TE, Kent M, HarcourtBrown TR, Carrera-Justiz SC, Gilmour LJ, Masciarelli AE, Jeffery ND (2022) Agreement and differentiation of intradural spinal cord lesions in dogs using magnetic resonance imaging. J Vet Intern Med. 2022 Jan;36(1):171-178.
Van Sandt RL, Welsh CJ, Jeffery ND, Young CR, McCreedy DA, Wright GA, Boudreau CE, Levine GJ, Levine JM (2022) Circulating neutrophil activation in dogs with naturally occurring spinal cord injury secondary to intervertebral disk herniation. Am J Vet Res. 2022 Jan 21;83(4):324-330.
Jones B, Behr S, Shaw T, Cappello R, Jeffery N, Liebel FX, Harcourt-Brown T (2022) Surgical techniques used in the management of intra-arachnoid diverticula in dogs across four referral centres and their immediate outcome. J Small Anim Pract. 2022 Feb 9. doi: 10.1111/jsap.13486.
Argent V, Perillo R, Jeffery N, Freeman P (2022) Recurrence of signs consistent with cervical intervertebral disc extrusion in dogs. J Small Anim Pract. 2022 Feb 10. doi: 10.1111/jsap.13480.
Ellinwood NM, Valentine BN, Hess AS, Jens JK, Snella EM, Jamil M, Hostetter SJ, Jeffery ND, Smith JD, Millman ST, Parsons RL, Butt MT, Chandra S, Egeland MT, Assis AB, Nelvagal HR, Cooper JD, Nestrasil I, Mueller BA, Labounek R, Paulson A, Prill H, Liu XY, Zhou H, Lawrence R, Crawford BE, Grover A, Cherala G, Melton AC, Cherukuri A, Vuillemenot BR, Wait JC, O'Neill CA, Pinkstaff J, Kovalchin J, Zanelli E, McCullagh E. Tralesinidase alfa enzyme replacement therapy prevents disease manifestations in a canine model of mucopolysaccharidosis type IIIB. J Pharmacol Exp Ther. 2022 Jun 18:JPET-AR-2022-001119. doi:10.1124/jpet.122.001119.
Khan S, Freeman P, Jeffery ND. Spontaneous resolution of severe disc-associated spinal cord compression in a dog. J Small Anim Pract. 2022 Jun 21. doi: 10.1111/jsap.13526.
Pilot MA, Lutchman A, Hennet J, Anderson D, Robinson W, Rossanese M, Chrysopoulos A, Demetriou J, De la Puerta B, Mullins RA, Brissot H, Jeffery N, Chanoit G. (2022) Comparison of median sternotomy closure-related complication rates using orthopedic wire or suture in dogs: A multi-institutional observational treatment effect analysis. Vet Surg 51: 990-1001. doi: 10.1111/vsu.13846.
Jeffery ND, Budke CM, Chanoit GP (2022) What is the value of statistical testing of observational data? Vet Surg Jul 10. doi: 10.1111/vsu.13845.
Rosen S, Grzegorzewski JL, Heath S, Schocke C, Jeffery N (2022). A 50-step walking test for analysis of recovery after decompressive surgery for thoracolumbar disc herniation in dogs. J Vet Int Med doi.org/10.1111/jvim.16516
Lovell S, Simon B, Boudreau EC, Mankin J, Jeffery N (2022) Randomized clinical trial comparing outcomes after fentanyl or ketamine-dexmedetomidine analgesia in thoracolumbar spinal surgery in dogs. J Vet Intern Med Aug 13. doi: 10.1111/jvim.16514.
Freeman P, Jeffery N (2022) Is decompression in acute thoracolumbar intervertebral disc herniation overvalued? Front Vet Sci. 2022 Nov 9;9:1049366. doi: 10.3389/fvets.2022.1049366.
Yi KC, Heseltine JC, Jeffery ND, Cook AK, Nabity MB (2023) Effect of withholding food versus feeding on creatinine, symmetric dimethylarginine, cholesterol, triglycerides, and other biochemical analytes in 100 healthy dogs. J Vet Intern Med 37: 626-634.
Jeffery N, Granger N (2023) New insights into the treatment of meningoencephalomyelitis of unknown origin since 2009: A review of 671 cases. Front Vet Sci 10: 1114798.
Evans JB, Lidbury JA, Jeffery N, Washburn SE, Patterson CA (2023) Hip sensor location for flash interstitial glucose monitoring system provides adequate clinical accuracy in non-diabetic hypoglycemic dogs. Am J Vet Res 84: ajvr.23.02.0024.
Biehl K, Rogovskyy AS, Jeffery N, Douglas P, Thieman Mankin KM (2023) Influence of closed glove exchange on bacterial contamination of the hands of the surgical team. Vet Surg 52: 747-755.
Matthews DJ, Fries RC, Jeffery ND, Hamer SA, Saunders AB (2023) Cardiac Magnetic Resonance Imaging Detects Myocardial Abnormalities in Naturally Infected Dogs with Chronic Asymptomatic Chagas Disease. Animals 13: 1393. 21
Glamann S, Jeffery ND, Levine JM, Gremillion CL, Gilmour LJ, Boudreau CE, Hecht S, Griffin JF 4th. (2023) The "Claw Sign" may aid in axial localization in cases of peripherally located canine glioma on MRI. Vet Radiol Ultrasound 64: 706-712.
Books
Jeffery ND (1995) Handbook of Small Animal Spinal Surgery. W.B. Saunders, London.
Book Chapters
Jeffery ND, Olby NJ (2003) Pathophysiology of diseases of the CNS. In: Textbook of Small Animal Surgery, Ed: DW Slatter, 3rd Edn,. W.B. Saunders.
Jeffery ND (2003) Tumours affecting the nervous system. In: BSAVA Handbook on Oncology, Eds: JM Dobson & BDX Lascelles, 2nd Edn. BSAVA Publications.
Jeffery ND (2004) Abnormalities of the head and face. In: BSAVA Handbook on Neurology, Eds: NJ Olby & SP Platt, 3rd Edn. BSAVA Publications.
Jeffery ND, Olby NJ (2011) Chapter 29: Pathogenesis and physiology of central nervous system disease and injury. In: Veterinary Surgery Small Animal, Eds Tobias KM & Johnston SA, 1st Edn., Elsevier. Pp 374-387.
Jeffery ND, Granger N (2012) Abnormalities of the head and face. In: BSAVA Handbook on Neurology, Eds: NJ Olby & SP Platt, 4th Edn. BSAVA Publications.
Jeffery ND, Granger N, Franklin RJM (2013) Chapter 9 Using Naturally Occurring spinal cord injury in domestic dogs to explore novel therapeutic options. In: Animal Models of spinal cord repair, Ed Aldskogius, H; Human Press, Springer, New York. Pp185-205
Jeffery ND (2015; 2018) Lumbosacral disease. In: 5 minute consults Jeffery ND (2017) Chapter 267: Spinal Cord Diseases: Traumatic, Vascular, and Neoplastic Disorders. Small Animal Medicine. Ettinger, Feldman, Cote.
Jeffery ND, Olby NJ (2017) Pathogenesis and physiology of central nervous system disease and injury. In: Veterinary Surgery Small Animal, Eds Tobias KM & Johnston SA, 2nd Edn., Elsevier.
Jeffery ND, Granger N (In press) Abnormalities of the head and face. In: BSAVA Handbook on Neurology, Eds: NJ Olby & SP Platt, 5th Edn. BSAVA Publications. (Update of previous chapter)
Jeffery ND (In press) Research projects in practice. In: BSAVA Textbook on Veterinary Nursing. BSAVA Publications. Jeffery N (In press) Research statistics. In: BSAVA Textbook on Veterinary Nursing. BSAVA Publications.
Editorials, Op-Ed Pieces, and Other Peer-Reviewed Publications
Jeffery ND, Budke CM, Chanoit GP (2023) Reply to letter to the Editor: What is the value of statistical testing of observational data? Vet Surg 52: 195.
Jeffery ND (2008) No shame in service to pets. Veterinary Times 38 (10): 8-9.
Jeffery ND (2008) Promoting inter-institutional collaboration: BVNSG methods. Veterinary Times 38 (14): 30-31.
Jeffery ND, Granger N (2012) Guest editorial, Is ‘stem cell therapy’ becoming 21st century snake oil? Veterinary Surgery 41: 189-190.
Jeffery ND (2014) Guest editorial, Canine epilepsy: in search of a fitting end. The Veterinary Journal Epub.
Jeffery N (2014) How lack of clarity in regulation is stifling veterinary research. Veterinary Record 174: 148-9.
Jeffery ND (2014) Editorial Ask not what your journal can do for you, ask what you can do for it. The Veterinary Journal.
Jeffery ND, Olby NJ (2014) Joint editors of ‘Advances in Small Animal Neurology’ Veterinary Clinics of North America, November 2014.
Jeffery N (2015) Editorial, Changes. J Small Anim Pract 56: 359
Jeffery N (2015) Editorial, Scaling the CRAG to smooth the path to publication in JSAP. J Small Anim Pract 56: 423-424.
Jeffery N (2015) Editorial, Liberating the (data) population from subjugation to the 5% (Pvalue). J Small Anim Pract 56: 483-484.
Jeffery N (2015) Editorial, 'There is no such thing as alternative medicine'. J Small Anim Pract 56: 687-8.
Jeffery N (2016) Editorial, Care to share? J Small Anim Pract 57: 501-502.
Jeffery N, Tivers MS (2018) Editorial, Prognostic markers: what are they good for? J Small Anim Pract 59: 321-323.
Jeffery N (2018) Editorial, CRAG rocks. J Small Anim Pract 59: 383-384. Jeffery N (2019) Some random comments on comparison studies. J Small Anim Pract 60: 203.
Day MJ, Jeffery N (2020) The needle and the damage prevented. J Small Anim Pract. doi: 10.1111/jsap.13145.
Moore SA, Tipold A, Olby NJ, Stein V, Granger N; Canine Spinal Cord Injury Consortium (CANSORT SCI) (2020) Current Approaches to the Management of Acute Thoracolumbar Disc Extrusion in Dogs. Front Vet Sci 7: 610. doi: 10.3389/fvets.2020.00610. eCollection 2020. *NJ as part of CANSORT.
Fenn J, Olby NJ; Canine Spinal Cord Injury Consortium (CANSORT-SCI) (2020) Classification of Intervertebral Disc Disease. Front Vet Sci 7: 579025. *NJ as part of CANSORT
Spitzbarth I, Moore SA, Stein VM, Levine JM, Kühl B, Gerhauser I, Baumgärtner W; Canine Spinal Cord Injury Consortium (CANSORT-SCI) (2020) Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury. Front Vet Sci 7:595796.
da Costa RC, De Decker S, Lewis MJ, Volk H; Canine Spinal Cord Injury Consortium (CANSORT-SCI) (2020) Diagnostic Imaging in Intervertebral Disc Disease. Front Vet Sci 7:588338.
Olby NJ, da Costa RC, Levine JM, Stein VM; Canine Spinal Cord Injury Consortium (CANSORT SCI) (2020) Prognostic Factors in Canine Acute Intervertebral Disc Disease. Front Vet Sci 7:596059. doi: 10.3389/fvets.2020.596059.
Granger N, Olby NJ, Nout-Lomas YS; Canine Spinal Cord Injury Consortium (CANSORT-SCI) (2020) Bladder and Bowel Management in Dogs With Spinal Cord Injury. Front Vet Sci 7:583342. doi: 10.3389/fvets.2020.583342
McBride R, Parker E, Garabed RB, Olby NJ, Tipold A, Stein VM, Granger N, Hechler AC, Yaxley PE, Moore SA; CANSORT-SCI study investigators (2022) Developing a predictive model for spinal shock in dogs with spinal cord injury. J Vet Intern Med 36:663-671.